|
KMID : 0366220050400010008
|
|
Korean Journal of Hematology
2005 Volume.40 No. 1 p.8 ~ p.14
|
|
|
Angioimmunoblastic T-cell Lymphoma: Clinical Characteristics and Treatment Outcomes
|
|
Baek Ji-Yeon
Park Sook-Ryun
Choi In-Sil
Kim Sang-Il
Kim Dong-Wan
Kim Jee-Hyun
Yoon Sung-Soo
Park Seon-Yang
Kim Byoung-Kook
Kim Noe-Kyeong
Heo Dae-Seok
|
|
|
Abstract
|
|
|
Background: An angioimmunoblastic T-cell lymphoma (AITL) is a rare subtype of lymphoma, accounting for only 1 to 2% of studies on non-Hodgkin’s lymphomas. Because of the rarity of this disease, most studies have been small, including cases of various T-cell Non-Hodgkin’s Lymphoma (T-NHL). Those patients diagnosed as AITL, during the last 8 years at a single institution (Seoul National University Hospital), were retrospectively analyzed to determine the clinical features and treatment outcomes of AITL.
Methods: All 24 of the patients diagnosed with AITL between February 1995 and February 2003 were included in this retrospective review.
Results: The predominant characteristics of the population were: median age 62 years (range, 32~81); M/F=18/6; nodal involvement 24/24 (100%); extranodal involvement, particularly bone marrow 16/20 (80%); skin involvement 6/24 (25%); B-symptoms 18/24 (75%) and advanced disease (stages III and IV) in 20/24 (83%). Twenty-three of the 24 patients received combination chemotherapy, with 8/23 (35%) of patients obtaining a CR. The median CR duration was 18.1 months. With a median follow-up of 40.9 months, the 5-year OS rate was 28%, with median survival of 8.7 months. According to a univariate analysis, an elevated LDH showed a tendency to negatively influence the survival.
Conclusion: The prognosis of AITL is poor compared to other NHL, with a low CR rate and short CR duration and OS. From our data, the CR rate after first- or second-line chemotherapy were low (35%), compared with those previously described in Western reports.
|
|
|
KEYWORD
|
|
|
Angioimmunoblastic, T-cell Lymphoma, Clinical features, Prognosis, Treatment
|
|
|
FullTexts / Linksout information
|
|
  
|
|
|
Listed journal information
|
|
  
|
|